Interdisciplinary Clinical Practice Guidelines for patient-centred management of juvenile-onset systemic lupus erythematosus

<h2>ABSTRACT</h2><h3>Objectives</h3> To develop updated interdisciplinary clinical practice guidelines for the management of juvenile-onset systemic lupus erythematosus (jSLE) in a patient-centred, treat-to-target (T2T) approach. <h3>Methods</h3> Recommendations were developed based on T2T principles around shared decision-making by a multidisciplinary team of experts including paediatric and adult rheumatologists, paediatric nephrologists, neurologists, cardiologists, pneumologists, radiologists, immunologists, and infectious disease specialists, geneticists, and ophthalmologists from Germany, Switzerland, Austria, the United Kingdom and Ireland, a psychologist, and a patient representative. The process followed the standard operating procedures of the German AWMF (Association of the Scientific Medical Societies in Germany). The team conducted an extensive literature review (2012-2024) of 40 clinically selected Population/Intervention/Comparison/Outcome questions. Overarching principles (OAP), overarching treatment strategies (OATS), and recommendations were formulated and explored in 2 online preconsensus meeting Delphi surveys with the experts. The results were discussed in 3 virtual consensus meetings using a modified nominal group technique to discuss, modify and vote on the OAP, OATS, and recommendations. All final document was approved by 2 external reviewers and the AWMF. <h3>Results</h3> We reached consensus on 45 recommendations on the general assessment, diagnosis, monitoring, nonpharmacologic, and pharmacologic management of jSLE. We highlight organ-specific manifestations, such as central nervous system disease, jSLE-related antiphospholipid antibody syndrome, and juvenile lupus nephritis, and consider disease severity for treatment recommendations. <h3>Conclusions</h3> We have developed updated interdisciplinary clinical practice guidelines to facilitate a patient-centred T2T approach to the management of patients with jSLE.

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Publication Details

Journal
EULAR Rheumatology Open
Published
2025-10-01
DOI
https://doi.org/10.1016/j.ero.2025.10.005
Citations
1
Primary Topic
Systemic Lupus Erythematosus Research
Type
article
Field-Weighted Citation Impact
1.67
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article

Interdisciplinary Clinical Practice Guidelines for patient-centred management of juvenile-onset systemic lupus erythematosus

Tilmann Kallinich, Christian M. Hedrich, Lutz T. Weber, Hermine I. Brunner et al.
1 citations
EULAR Rheumatology Open
Systemic Lupus Erythematosus Research
1.67
article

Interdisciplinary Clinical Practice Guidelines for patient-centred management of juvenile-onset systemic lupus erythematosus

Tilmann Kallinich, Christian M. Hedrich, Lutz T. Weber, Hermine I. Brunner, Aleš Janda, Susanne M. Benseler, Dirk Kamitz, Dieter Haffner, Min Ae Lee‐Kirsch, Heike Hoyer‐Kuhn, Fabian Speth, Kirsten Mönkemöller, Sabine Schanze, Nicolaus Schwerk, Klaus Tenbrock, Martin Aringer, Claas Hinze, Matthias Schneider, Norbert Wagner, Jörg Reichert, Catharina Schuetz, Anton Hospach, Ulrich Neudorf, Martin Häusler, C P Bieber, Jürgen Brunner, Burkhard Tönshoff, Gabriele Hahn, Christoph Deuter, Merle Seume
article en
1 citations

Abstract

<h2>ABSTRACT</h2><h3>Objectives</h3> To develop updated interdisciplinary clinical practice guidelines for the management of juvenile-onset systemic lupus erythematosus (jSLE) in a patient-centred, treat-to-target (T2T) approach. <h3>Methods</h3> Recommendations were developed based on T2T principles around shared decision-making by a multidisciplinary team of experts including paediatric and adult rheumatologists, paediatric nephrologists, neurologists, cardiologists, pneumologists, radiologists, immunologists, and infectious disease specialists, geneticists, and ophthalmologists from Germany, Switzerland, Austria, the United Kingdom and Ireland, a psychologist, and a patient representative. The process followed the standard operating procedures of the German AWMF (Association of the Scientific Medical Societies in Germany). The team conducted an extensive literature review (2012-2024) of 40 clinically selected Population/Intervention/Comparison/Outcome questions. Overarching principles (OAP), overarching treatment strategies (OATS), and recommendations were formulated and explored in 2 online preconsensus meeting Delphi surveys with the experts. The results were discussed in 3 virtual consensus meetings using a modified nominal group technique to discuss, modify and vote on the OAP, OATS, and recommendations. All final document was approved by 2 external reviewers and the AWMF. <h3>Results</h3> We reached consensus on 45 recommendations on the general assessment, diagnosis, monitoring, nonpharmacologic, and pharmacologic management of jSLE. We highlight organ-specific manifestations, such as central nervous system disease, jSLE-related antiphospholipid antibody syndrome, and juvenile lupus nephritis, and consider disease severity for treatment recommendations. <h3>Conclusions</h3> We have developed updated interdisciplinary clinical practice guidelines to facilitate a patient-centred T2T approach to the management of patients with jSLE.

EULAR Rheumatology OpenVol. 1(4)
Cincinnati Children's Hospital Medical Center (US), Innsbruck Medical University (AT), University of Liverpool (GB), Universität Hamburg (DE), University of Calgary (CA), University of Cologne (DE), Universität Ulm (DE), Heidelberg University (DE), University Hospital of Bern (CH), University Hospital Heidelberg (DE), Children's Health Ireland at Crumlin (IE), Medizinische Hochschule Hannover (DE), German Center for Pediatric and Adolescent Rheumatology (DE), Alder Hey Children's NHS Foundation Trust (GB), German Rheumatism Research Centre (DE), University Hospital Münster (DE), University Medical Center Hamburg-Eppendorf (DE), Essen University Hospital (DE), University Children’s Hospital Basel (CH), Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE), Altonaer Kinderkrankenhaus (DE), STZ eyetrial (DE), European Society of Cutaneous Lupus Erythematosus (DE), University Hospital Cologne (DE), Klinikum Stuttgart (DE), University Hospital Carl Gustav Carus (DE), Heinrich Heine University Düsseldorf (DE), Technische Universität Dresden (DE), Charité - Universitätsmedizin Berlin (DE), RWTH Aachen University (DE)
Openalex Percentile: Top 12%
Systemic Lupus Erythematosus Research
1.67
DOIOpen Access PDFOpenAlex
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