Acute immunometabolic changes in first-presentation Graves’ hyperthyroidism patients undergoing strenuous physical activity

This study, for the first time, systematically evaluated immunometabolic responses in female Graves' hyperthyroidism patients following HIIE. While muscle loss in newly diagnosed hyperthyroidism patients did not significant impair short-term explosive power, it may reduce endurance during sustained high-intensity exercise. The hyperthyroid state markedly altered exercise-induced immunometabolic dynamics, underscoring the need for comprehensive consideration of hyperthyroidism's complex physiological impact when designing personalized exercise regimens.