Enteropathy-associated t-cell lymphoma presenting as refractory cutaneous ulcers in a 28-year-old male: a case report and literature review
This case underscores that EATL may manifest with widespread cutaneous ulcers more than one year before the onset of severe gastrointestinal symptoms. In patients with chronic diarrhea and refractory skin ulcers, celiac disease should be excluded, while cutaneous lesions should be recognized as potential paraneoplastic manifestations of an underlying lymphoma. Diagnostic delays-driven by anchoring bias and insufficient tissue sampling-are critical contributors to advanced disease at presentation and poor clinical outcomes.
Authors
- Yanan Zhao (ORCID: https://orcid.org/0000-0002-1532-3641)
- Quan‐Lin Li (ORCID: https://orcid.org/0000-0002-9108-8786)
- Dan Liu (ORCID: https://orcid.org/0000-0002-5731-9122)
- Ming Liu (ORCID: https://orcid.org/0000-0002-8662-3190)
- Zheng Liu (ORCID: https://orcid.org/0000-0002-7241-3483)
- Jie Xu (ORCID: https://orcid.org/0000-0002-1897-1644)
- Dejie Zhao
- Zhixin Cheng
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Beijing Royal Integrative Medicine Hospital (CN)
- Affiliated Hospital of Shandong University of Traditional Chinese Medicine (CN)
- Beijing Chaoyang Emergency Medical Center (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-11-21
- DOI
- https://doi.org/10.3389/fonc.2025.1716730
- Primary Topic
- Cutaneous lymphoproliferative disorders research
- Type
- article
- Field-Weighted Citation Impact
- 0.00