Mucosal B Cell Expansion and Maturation Contribute to Colitis Pathogenesis
Our findings suggest that naive B cells expand in actively inflamed mucosa from UC patients and play a pathogenic role in experimental colitis.
Authors
- Jan Verhoeff (ORCID: https://orcid.org/0000-0003-0648-0642)
- Wouter J. de Jonge (ORCID: https://orcid.org/0000-0002-3241-1547)
- Lieven G.M. Mulders (ORCID: https://orcid.org/0000-0003-1001-1291)
- Manon E. Wildenberg (ORCID: https://orcid.org/0000-0003-0671-818X)
- P J Koelink (ORCID: https://orcid.org/0000-0002-8403-3082)
- Iris Admiraal (ORCID: https://orcid.org/0000-0003-3335-4924)
- Geert D’Haens (ORCID: https://orcid.org/0000-0003-2784-4046)
- Andrew Y. F. Li Yim (ORCID: https://orcid.org/0000-0002-0754-0953)
- Caroline Verseijden (ORCID: https://orcid.org/0009-0001-9284-5734)
- Yi Luo (ORCID: https://orcid.org/0000-0003-0087-5045)
- Ivan C N Fung (ORCID: https://orcid.org/0009-0008-5333-0915)
Institutions
- University of Bonn (DE)
- Bristol-Myers Squibb (United States) (US)
- Amsterdam Neuroscience (NL)
- Bristol-Myers Squibb (Belgium) (BE)
- Amsterdam University Medical Centers (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Inflammatory Bowel Diseases
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1093/ibd/izaf275
- Citations
- 1
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Bristol-Myers Squibb
- Amsterdam University Medical Centers
- Janssen Prevention Center