Evaluation of expression profiles of APOA4, CEACAM1, CD147, DJ-1/PARK7, Gamma-synuclein, S100A1, and Stathmin-1 in urothelial carcinomas using immunohistochemical assays
A biomarker panel comprising Stathmin-1, DJ-1/PARK7, Gamma-synuclein, and APOA4 reliably distinguished urothelial carcinoma from benign urothelium. These markers, when integrated with cytology, could enhance the diagnostic precision and reduce dependence on invasive cystoscopy. The proposed cutoffs (10%-20% positive cells or Allred score ≤2) offer clinically actionable threshold for histopathological practice.
Authors
- Naveed Sharif (ORCID: https://orcid.org/0000-0002-4550-8604)
- Umar Nishan (ORCID: https://orcid.org/0000-0002-0106-3068)
- Asif Ali (ORCID: https://orcid.org/0000-0002-3480-0060)
- Hussah M. Alobaid (ORCID: https://orcid.org/0000-0001-6478-1238)
- Sher Zaman Safi (ORCID: https://orcid.org/0000-0003-1864-4712)
- Nawshad Muhammad (ORCID: https://orcid.org/0000-0001-6453-0658)
- Walayat Shah
- Sajid Ali (ORCID: https://orcid.org/0000-0002-3654-6529)
- Syed A. A. Rizv
Institutions
- Qassim University (SA)
- Kohat University of Science and Technology (PK)
- Khyber Medical University (PK)
- King Saud University (SA)
- Larkin University (US)
- Mahsa University (MY)
- University of Glasgow (GB)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-11-21
- DOI
- https://doi.org/10.3389/fonc.2025.1587558
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- King Saud University