Potential anti-apoptotic response in the induced T regulatory cells in the burn vs. burn-plus-peritonitis-injured animals 3307

Abstract Description Actions of the mediators and cell-cell interactions presumably lead to the inhibition of the CD4+CD25- effector T cell proliferation and IL-2 production. We evaluated such potential actions of induced Treg (CD4+CD25+) cells (in PPs and MLNs) of 1) burn alone, 2) peritonitis alone, and 3) burn plus peritonitis injured animals. Our results have indicated that Treg cells induced during burn injury exhibit decreased apoptosis. This might imply that a decrease in their apoptotic rate might reinforce the potential inhibitory effects of the Treg cells. We found an apoptotic rate decrease in the induced Treg, which resulted from the actions of burn and burn-plus-peritonitis-related antigens. Furthermore, we evaluated if there was a difference in the extent of potential anti-apoptotic response in the induced Treg cells in the burn vs. burn-plus-peritonitis-injured animals. Our results suggest a more significant decrease in Treg cells’ apoptosis in the burn/peritonitis group, implying a prolonged “suppressive” effect on the CD4+ helper T cells in the combined injury condition. The data points out that there might be differences in the impact of these three injury conditions that may be consequential in determining the morbidity and mortality of injured hosts in these conditions. Other experiments in this series would assess mechanisms by which CD4+CD25+ T cells could down-regulate CD4+ helper T cells. Funding Sources CTRE Chicago State University Topic Categories Immune Response Regulation: Cellular Mechanisms (IRC)