Statin Use Is Associated With a Decline in Muscle Function and Mass Over Time, Irrespective of Statin Pharmacogenomic Score
Continuous statin use is associated with a decline in muscle function and mass over time (25% decline in grip strength and 73% decline in ALM compared to never-users), irrespective of genetic susceptibility to statin response. This study emphasizes the importance of monitoring musculoskeletal health in statin users and supports further research into the potential role of a healthy diet and regular physical activity in preserving muscle function, which may also reinforce the cardiovascular benefits of statin therapy.
Authors
- Olga E. Titova (ORCID: https://orcid.org/0000-0003-2747-1606)
- Mélissa Gentreau (ORCID: https://orcid.org/0000-0002-4070-1229)
- Salahuddin Mohammad (ORCID: https://orcid.org/0000-0002-6050-4708)
- Gull Rukh (ORCID: https://orcid.org/0000-0003-0000-7694)
- Ahmed M. Alsehli
- Helgi B. Schiöth (ORCID: https://orcid.org/0000-0001-7112-0921)
- M.D. KHALED A. EL-GHAMRAWY LOBNA Kh. SAKR
Institutions
- Uppsala University (SE)
- King Abdulaziz University (SA)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1002/jcsm.70132
- Citations
- 1
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- Vetenskapsrådet