Running on the edge: hematological responses to a non-stop ultramarathon with a focus on nitric oxide–mediated red blood cell deformability
Overall, the ultramarathon induced complex but compensatory adaptations in the RBC system, where NO-mediated improvements in deformability may counteract stress-induced risks to cell integrity. Thus, despite no acute impairment of RBC function, adequate hydration, antioxidant-rich nutrition, and sufficient recovery may be emphasized to safeguard long-term RBC health in extreme endurance exercise.
Authors
- Michael Siebers (ORCID: https://orcid.org/0000-0003-1891-3572)
- Moritz Munk (ORCID: https://orcid.org/0000-0002-4977-1901)
- Lucas John (ORCID: https://orcid.org/0000-0001-7602-2239)
- Wilhelm Bloch
- Daniel Alexander Bizjak (ORCID: https://orcid.org/0000-0003-4075-0204)
- J. Bruns (ORCID: https://orcid.org/0000-0001-8802-1022)
- Marijke Grau (ORCID: https://orcid.org/0000-0003-1980-9195)
- Magnus Stücher
- Christoph Siebers
Institutions
- German Sport University Cologne (DE)
- University Hospital Ulm (DE)
- University of Duisburg-Essen (DE)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2025-11-21
- DOI
- https://doi.org/10.3389/fphys.2025.1715513
- Primary Topic
- Exercise and Physiological Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00