Antidiabetic and lipid-lowering therapy modify the association between triglyceride–glucose index and acute kidney injury in critically ill patients with coronary artery disease
In critically ill CAD patients, a higher TyG index was independently associated with an increased risk of AKI, whereas this association was attenuated in those with the use of antidiabetic or lipid-lowering drugs. These findings highlight the importance of incorporating metabolic risk assessment into the management of critically ill patients and underscore the potential of pharmacological interventions to improve renal outcomes.
Authors
- Hanshen Luo
- Xiang Qiu (ORCID: https://orcid.org/0000-0001-9161-9033)
- Xiangying Jiao (ORCID: https://orcid.org/0000-0003-1182-9052)
- Linfeng He (ORCID: https://orcid.org/0000-0001-7211-1170)
- Chao Shi (ORCID: https://orcid.org/0000-0002-3808-8699)
- Ding Li (ORCID: https://orcid.org/0000-0002-7048-822X)
- Jiawei Shi (ORCID: https://orcid.org/0000-0002-0643-7671)
- Yuehang Yang
Institutions
- Nanchang University (CN)
- Karolinska Institutet (SE)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Second Affiliated Hospital of Nanchang University (CN)
- Wuhan Union Hospital (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-11-21
- DOI
- https://doi.org/10.3389/fendo.2025.1699936
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province