Differential response of the thyroid axis to high-fat diet-induced inflammation and energy balance deregulation in juvenile and adult rats
Prolonged exposure promoted IL-1β-associated neuroinflammation, altered HPT axis regulation and favored leptin resistance, particularly in juveniles. These results highlighted the critical role of developmental stage and diet duration in HFD intake neuroendocrine effects.
Authors
- Elena Alvarez‐Salas (ORCID: https://orcid.org/0000-0002-0136-3319)
- André Furugen Cesar de Andrade (ORCID: https://orcid.org/0000-0002-0148-4372)
- Patricia de Gortari (ORCID: https://orcid.org/0000-0002-9402-2061)
- Cinthia García-Luna (ORCID: https://orcid.org/0000-0002-9401-1856)
- Gilberto Matamoros‐Trejo
- Paulina Soberanes-Chávez (ORCID: https://orcid.org/0000-0002-1924-4617)
- Juan Luis Dolores-SanJuan
Institutions
- Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz (MX)
- Institute for Social Security and Services for State Workers (MX)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-11-21
- DOI
- https://doi.org/10.3389/fendo.2025.1676754
- Primary Topic
- Regulation of Appetite and Obesity
- Type
- article
- Field-Weighted Citation Impact
- 0.00