Efficacy and influencing factors of immunosuppressive therapy combined with or without eltrombopag in children with severe aplastic anemia
EPAG combined with IST shows comparable efficacy to cyclosporine alone in children with SAA, along with a favorable safety profile. Patients with earlier initiation of EPAG and preserved residual hematopoietic function are more likely to achieve remission, without serious adverse reactions or significant clonal evolution.
Authors
- Ju Gao (ORCID: https://orcid.org/0009-0003-4765-4554)
- Xianmin Guan (ORCID: https://orcid.org/0009-0003-2282-8730)
- Jiebin Qin
- Feng Ye (ORCID: https://orcid.org/0000-0002-5953-6024)
- Hui Yang (ORCID: https://orcid.org/0009-0006-7774-0199)
- Meiling Liao
- Xianhao Wen
- Mingzhu Luo
Institutions
- Children's Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-11-21
- DOI
- https://doi.org/10.3389/fmed.2025.1688771
- Primary Topic
- Hematopoietic Stem Cell Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chongqing Municipal Health Commission