Clinical features and HLA typing of immune checkpoint inhibitor-associated myasthenia gravis, myocarditis and myositis
Our research findings reveal that patients carrying autoimmune susceptibility genes have a higher risk of developing irAEs when treated with ICI, specific HLA alleles may be associated with the risk of ICI-related MG/myositis/myocarditis, but further large-scale, multi-center validation is needed.
Authors
- Guoyan Qi (ORCID: https://orcid.org/0000-0001-9218-3219)
- Xiaoting Lin
- Peng Liu (ORCID: https://orcid.org/0000-0002-1682-9222)
- Min Jin (ORCID: https://orcid.org/0000-0001-9317-0647)
Institutions
- North China University of Science and Technology (CN)
- Hebei Chemical and Pharmaceutical College (CN)
- Hebei General Hospital (CN)
- First Hospital of Shijiazhuang (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-11-21
- DOI
- https://doi.org/10.3389/fonc.2025.1646231
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China