The role of genes related to excitotoxicity in glioma prognosis

Our bioinformatics analysis reveals a significant association between an ERGs signature and glioma prognosis, providing a novel prognostic risk model with strong predictive capabilities. The identified pathways and immune cell infiltration patterns highlight potential therapeutic targets and suggest a role for the tumor microenvironment in glioma progression. These findings warrant further in vitro and in vivo validation to translate bioinformatics discoveries into personalized therapies that improve clinical outcomes.

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Publication Details

Journal
Discover Oncology
Published
2025-11-21
DOI
https://doi.org/10.1007/s12672-025-04025-6
Primary Topic
Glioma Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

The role of genes related to excitotoxicity in glioma prognosis

Qiang Zhao, Kunpeng Du
Discover Oncology
Glioma Diagnosis and Treatment
article

The role of genes related to excitotoxicity in glioma prognosis

Qiang Zhao, Kunpeng Du
article en

Abstract

Our bioinformatics analysis reveals a significant association between an ERGs signature and glioma prognosis, providing a novel prognostic risk model with strong predictive capabilities. The identified pathways and immune cell infiltration patterns highlight potential therapeutic targets and suggest a role for the tumor microenvironment in glioma progression. These findings warrant further in vitro and in vivo validation to translate bioinformatics discoveries into personalized therapies that improve clinical outcomes.

Discover OncologyVol. 16(1)
Tianjin Medical University Cancer Institute and Hospital (CN), Zhujiang Hospital (CN)
Openalex Percentile: Top 49%
Glioma Diagnosis and Treatment
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