The role of genes related to excitotoxicity in glioma prognosis
Our bioinformatics analysis reveals a significant association between an ERGs signature and glioma prognosis, providing a novel prognostic risk model with strong predictive capabilities. The identified pathways and immune cell infiltration patterns highlight potential therapeutic targets and suggest a role for the tumor microenvironment in glioma progression. These findings warrant further in vitro and in vivo validation to translate bioinformatics discoveries into personalized therapies that improve clinical outcomes.
Authors
- Qiang Zhao (ORCID: https://orcid.org/0000-0003-4847-7054)
- Kunpeng Du (ORCID: https://orcid.org/0000-0002-6462-4598)
Institutions
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Zhujiang Hospital (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1007/s12672-025-04025-6
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00