Vinblastine sulfate and allicin suppress growth in U87MG human glioblastoma cells 2514

Abstract Description The U87MG cells, derived from Uppsala 87 Malignant Glioma, represent one of the most aggressive forms of glioblastoma, characterized by mutations in PTEN, PI3K, and Akt genes that result in rapid tumor growth. These tumors significantly impair patients’ cognitive, motor, speech, sensory, and emotional functions, with a survival rate of only 5-10% and no known cure. This study aimed to evaluate the effects of vinblastine sulfate, a chemotherapeutic agent with promising efficacy in leukemia, and garlic-derived allicin, known for its protective effects on healthy cells, on U87MG glioblastoma cell growth. By treating the cells with varying concentrations of vinblastine sulfate and allicin, we sought to reduce cell viability and inhibit tumor growth. Results demonstrated a measurable decrease in viable cell count and overall growth suppression of U87MG cells. These findings suggest potential avenues for further exploration of natural and chemotherapeutic agents in targeting highly aggressive glioblastoma cells and warrant additional studies to confirm their efficacy in glioblastoma treatment strategies. Topic Categories Tumor Immunology: Checkpoints, Prevention, and Treatment (TIPT)