Elevated plasma soluble epoxide hydrolase was positively correlated with markers of liver injury and pro-inflammatory cytokines IL-8 and IL-1β in patients with alcohol-associated liver disease 2499

Abstract Description Alcohol-associated liver disease (ALD) is a significant global public health concern. Alcohol-associated hepatitis (AH), an acute and often severe form of ALD, is linked to substantial morbidity and mortality. However, mechanisms of ALD development and progression are not fully understood, and reliable biomarkers of disease severity are limited. The current study aimed to examine plasma soluble epoxide hydrolase (sEH), an enzyme that converts bioactive lipid-derived epoxides to less active/inactive molecules, in patients with ALD. Since sEH has been implicated in various pathological conditions, we further investigated its potential associations with liver injury and systemic inflammation. Our data demonstrated that plasma sEH levels were elevated in patients with early-stage ALD and moderate AH (mAH) compared to healthy non-drinking controls. In patients with early-stage ALD, sEH levels positively correlated with markers of liver injury, including ALT, AST, CK 18 M65, and total and direct bilirubin. In patients with mAH, sEH levels showed positive associations with elevated levels of plasma pro-inflammatory cytokines IL-8 and IL-1β. These findings suggest that sEH may play a role in ALD pathogenesis, and that elevated sEH levels may reflect the extent of liver injury in patients with early ALD and the severity of inflammation in patients with mAH. Further studies are needed to investigate sEH-mediated molecular mechanisms that contribute to ALD development and progression. Funding Sources NIH/NIAAA AA028905-01A1 Topic Categories Immune Mechanisms of Human Disease (HUM)