Common and divergent dynamic changes of the human plasma metabolome across the first week of life in the Gambia and Papua New Guinea 3859

Abstract Description Background The plasma metabolome changes markedly over the first week of life, yet little is known regarding how these trajectories might differ across geographically distinct populations. Methods To gain insight into potential differences in ontogeny between geographic sites, newborn participants were enrolled in The Gambia (n = 45) and Papua New Guinea (n = 45). All participants had samples collected at birth and were randomized to have their second sample collected either on the first, third, or seventh day following birth. Global untargeted plasma metabolomics employed ultra-performance liquid chromatography mass spectrometry (Metabolon). Results PCA showed plasma metabolites clustering by day of sample collection and by site. The majority (62%) of metabolite features showed a significant difference based on time point: 46% of these were lipids and 17% were amino acids. Additionally, 24% of the metabolite features showed a significant difference between sites, with the most common being lipids (28.2%). Xenobiotics including caffeine and food metabolites were distinct in GAM vs. PNG, suggesting differences in maternal diet and environmental factors. Conclusions The plasma metabolome undergoes marked changes during the first week of human life, with distinct features across geographic locations, and warrants further exploration with respect to potential correlations to immune status and clinical outcomes, with particular emphasis on lipid pathways. Funding Sources Supported by NIH/NIAID grants: U19AI118608 and U19AI168643–01, as well as the BCH Precision Vaccines Program. Topic Categories Computational and Systems Immunology (COMP)

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Publication Details

Journal
The Journal of Immunology
Published
2025-11-01
DOI
https://doi.org/10.1093/jimmun/vkaf283.1611
Primary Topic
Metabolomics and Mass Spectrometry Studies
Type
article
Field-Weighted Citation Impact
0.00

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article

Common and divergent dynamic changes of the human plasma metabolome across the first week of life in the Gambia and Papua New Guinea 3859

Joann Diray‐Arce, Olubukola T. Idoko, Anita H.J. van den Biggelaar, Kerry McEnaney et al.
The Journal of Immunology
Metabolomics and Mass Spectrometry Studies
article

Common and divergent dynamic changes of the human plasma metabolome across the first week of life in the Gambia and Papua New Guinea 3859

Joann Diray‐Arce, Olubukola T. Idoko, Anita H.J. van den Biggelaar, Kerry McEnaney, Jessica Ann Lasky-Su, Oludare A. Odumade, Asimenia Angelidou, Annmarie Hoch, Rebecca L. Ford, Tobias R. Kollmann, Peter Richmond, Kinga K. Smolen, William S. Pomat, Geraldine Masiria, Ofer Levy, Beate Kampmann, Al Ozonoff, Rym Ben-Othman, Caitlin Syphurs, Jing Chen, Joe Jude
article en

Abstract

Abstract Description Background The plasma metabolome changes markedly over the first week of life, yet little is known regarding how these trajectories might differ across geographically distinct populations. Methods To gain insight into potential differences in ontogeny between geographic sites, newborn participants were enrolled in The Gambia (n = 45) and Papua New Guinea (n = 45). All participants had samples collected at birth and were randomized to have their second sample collected either on the first, third, or seventh day following birth. Global untargeted plasma metabolomics employed ultra-performance liquid chromatography mass spectrometry (Metabolon). Results PCA showed plasma metabolites clustering by day of sample collection and by site. The majority (62%) of metabolite features showed a significant difference based on time point: 46% of these were lipids and 17% were amino acids. Additionally, 24% of the metabolite features showed a significant difference between sites, with the most common being lipids (28.2%). Xenobiotics including caffeine and food metabolites were distinct in GAM vs. PNG, suggesting differences in maternal diet and environmental factors. Conclusions The plasma metabolome undergoes marked changes during the first week of human life, with distinct features across geographic locations, and warrants further exploration with respect to potential correlations to immune status and clinical outcomes, with particular emphasis on lipid pathways. Funding Sources Supported by NIH/NIAID grants: U19AI118608 and U19AI168643–01, as well as the BCH Precision Vaccines Program. Topic Categories Computational and Systems Immunology (COMP)

The Journal of ImmunologyVol. 214(Supplement_1)
University of London (GB), Brigham and Women's Hospital (US), Boston Children's Hospital (US), Dalhousie University (CA), Harvard University (US), Hadassah Medical Center (IL), London School of Hygiene & Tropical Medicine (GB), Theranostics (New Zealand) (NZ), Boston Children's Museum (US), Papua New Guinea Institute of Medical Research (PG)
Pew Charitable Trusts, Searle Scholars Program
Openalex Percentile: Top 68%
Metabolomics and Mass Spectrometry Studies
DOIOpen Access PDFOpenAlex
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