Potentials of presepsin as a novel sepsis biomarker in critically ill adults. Correlation analysis with current diagnostic markers 2031

Abstract Description Background Sepsis is a major cause of patient death in intensive care units (ICU), hence identifying novel biomarkers of sepsis is crucial to aim in rapid diagnosis of sepsis and early intervention, which collectively improves outcome. Method This study involves 129 critically ill adults, categorized into three groups: sepsis (Se = 48), pneumonia (Pn = 48) and Se/Pn (33). Concentrations of five plasma markers (IL-6, IL-8, TREM1, uPAR and presepsin) were compared with 13 well-established measures of in critically ill patients. These measures were heart rate (HR), white blood count (WBC), sepsis, namely: C-reactive protein (CRP), procalcitonin (PCT), lactate plasma concentrations, and indicators of hemostasis status. Plasma bilirubin and creatinine served as indicators of liver and kidney dysfunction, respectively. Results Promising roles for these biomarkers were found. The best results were for presepsin, which scored 10/13, followed by IL-6 and IL-8 (each scored 7/13), and least were TREM-1 and uPAR (scored 3/13). Presepsin, IL-6, and IL-8 discriminated between the sepsis sub-types, whilst only presepsin correlated with bilirubin and creatinine. uPAR was positive for kidney dysfunction and TREM-1 was the only indicator artificial ventilation (AV). Conclusions Presepsin is an important potential biomarker in sepsis. However, further work is needed to define this marker’s diagnostic and prognostic cutoff values. Funding Sources - Arabian Gulf University - AGU/RCSI joint grant Topic Categories Translational and Interventional Immunology (TI)