scRNA-sequencing uncovers dysregulated androgen and lipid metabolism signaling pathway genes in keloids of understudied skin types 2584

Abstract Description Keloids are elevated, fibrous skin lesions that arise from excessive collagen production during the healing process. Typically developing after injuries, surgeries, or acne, they can vary in size and color. Keloids often cause cosmetic concern and discomfort, presenting challenges for treatment and effective management in patients with skin of color (SoC). In this study, we performed scRNA-seq on keloid samples from ten patients with SoC and compared them to six normal skin controls to elucidate molecular mechanisms underlying keloid formation. Our analysis revealed increased expression of genes associated with androgen signaling, highlighting a potential role for androgens in keloid pathogenesis. Furthermore, we identified upregulated genes related to lipid metabolism, suggesting that enhanced lipid storage and fatty acid binding may be implicated in keloid tissue development. The interplay between androgen signaling and lipid metabolism influences extracellular matrix synthesis and inflammatory responses, both central to keloid lesions. Our findings identify androgen and lipid metabolism pathways as promising therapeutic targets, warranting further investigation into their roles in keloid formation. Topic Categories Immune Mechanisms of Human Disease (HUM)