Multi-omics reveals that Sirt2 and Sirt5 differentially control macrophage polarization 3707

Abstract Description Macrophages (MΦs) are the preeminent phagocytic cells that control intracellular and extracellular infections using a variety of anti-microbial mechanisms. Our recent studies indicate that the expression of sirtuin protein, SIRT5, and SIRT2, is significantly different in M1- and M2-MΦs, together with significant changes of acetylation of histones and metabolism. here, we report using multi-omics to study the metabolic-epigenetic crosstalk that controls macrophage polarization and activation. This study sheds a light on the mechanism of macrophage polarization by sirtuin proteins. Funding Sources 1R01AI184551-01 R01 AI161015-01 Topic Categories Innate Immune Responses and Host Defense: Molecular Mechanisms (INM)