Dual Catalytic Enantioconvergent Carbamoylation of Aziridines
Herein, we disclose an enantioconvergent carbamoylation of racemic aziridines enabled by a dual catalytic strategy. The method offers a new entry point to highly enantioenriched β-amino amides from simple precursors and is characterized by its broad applicability, even with challenging combinations. Preliminary studies with well-defined nickel complexes support a scenario via carbamoyl organometallic intermediates.
Authors
- Rubén Martı́n (ORCID: https://orcid.org/0000-0002-2543-0221)
- Tomás G. Santiago (ORCID: https://orcid.org/0000-0003-4308-8324)
- Liangliang Zhang (ORCID: https://orcid.org/0000-0001-7637-8702)
- Huilin Liu
Institutions
- Institució Catalana de Recerca i Estudis Avançats (ES)
- Institut Català d'Investigació Química (ES)
- Universitat Rovira i Virgili (ES)
Publication Details
- Journal
- Journal of the American Chemical Society
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1021/jacs.5c15873
- Citations
- 1
- Primary Topic
- Synthesis and Catalytic Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.94