Peroxisomal dysfunction in cardiac adipose tissue is involved in obesity-associated cardiac hypertrophy
Our findings demonstrate that peroxisomal dysfunction in cardiac adipose tissue drives lipid metabolic reprogramming and contributes to obesity-related cardiac hypertrophy. Targeting peroxisomal function in cardiac fat could be a novel therapeutic approach to mitigate obesity-induced cardiovascular remodeling.
Authors
- Gahee Song (ORCID: https://orcid.org/0000-0002-3754-8294)
- Woo Yong Park (ORCID: https://orcid.org/0000-0003-4188-3826)
- Hyun Jeong Kwak (ORCID: https://orcid.org/0000-0001-7070-6066)
- Wenjun Jiao (ORCID: https://orcid.org/0000-0001-5458-0440)
- In Jin Ha (ORCID: https://orcid.org/0000-0002-9210-1401)
- Yunju Jo (ORCID: https://orcid.org/0000-0002-6305-3324)
- Jae‐Young Um (ORCID: https://orcid.org/0000-0002-0568-9738)
- Kuk Hui Son (ORCID: https://orcid.org/0000-0002-0595-5645)
- Dongryeol Ryu (ORCID: https://orcid.org/0000-0002-5335-6209)
- Peter K. Kim (ORCID: https://orcid.org/0000-0001-6626-0575)
- Seong-Kyu Choe
- Ja Yeon Park (ORCID: https://orcid.org/0009-0003-2107-5087)
- Se Jin Jung
Institutions
- Kookmin University (KR)
- Kyung Hee University (KR)
- Gwangju Institute of Science and Technology (KR)
- Dunsan Korean Medicine Hospital (KR)
- Gachon University Gil Medical Center (KR)
- Wonkwang University (KR)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1016/j.jare.2025.11.031
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00