Circulating Testican-2 and MGT5A are Markers of Membranous Nephropathy
Together, these findings motivate interest in testican-2 and MGT5A as markers and potential functional participants in MN. More work is required to understand the biological role of these proteins in the glomerular basement membrane in relation to immune complex deposition as well as to assess their performance as biomarkers alongside circulating autoantibodies in patients with MN.
Authors
- Laurence H. Beck (ORCID: https://orcid.org/0000-0003-1482-4089)
- Claire Trivin-Avillach
- Ivy A. Rosales (ORCID: https://orcid.org/0000-0003-0621-3202)
- Anand Srivastava (ORCID: https://orcid.org/0000-0002-8109-1420)
- Viji Nair (ORCID: https://orcid.org/0000-0003-1657-954X)
- Donghai Wen (ORCID: https://orcid.org/0000-0003-2707-036X)
- Aditya Surapaneni (ORCID: https://orcid.org/0000-0003-4978-5980)
- Jarcy Zee (ORCID: https://orcid.org/0000-0003-0586-1160)
- Isaac E. Stillman (ORCID: https://orcid.org/0000-0002-4224-5060)
- Insa Marie Schmidt (ORCID: https://orcid.org/0000-0002-0420-6570)
- Matthias Kretzler (ORCID: https://orcid.org/0000-0003-4064-0582)
- Ragnar Pálsson (ORCID: https://orcid.org/0000-0002-7104-9296)
- Wenjun Ju (ORCID: https://orcid.org/0000-0002-9136-8454)
- Yang Li (ORCID: https://orcid.org/0000-0002-0930-206X)
- Tae Soo Kim (ORCID: https://orcid.org/0000-0002-3902-1058)
- Damian Fermin (ORCID: https://orcid.org/0000-0001-9678-6834)
Institutions
- Boston University (US)
- University of Michigan (US)
- University of Illinois Chicago (US)
- NYU Langone Health (US)
- Massachusetts General Hospital (US)
- University of Pennsylvania (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Kidney International Reports
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1016/j.ekir.2025.11.020
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Nephcure Foundation
- Alport Syndrome Foundation
- Rare Diseases Clinical Research Network
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of Neurological Disorders and Stroke
- National Center for Advancing Translational Sciences