Plasma exchange as potential treatment of severe immune checkpoint inhibitor-induced hepatitis
Severe immune checkpoint inhibitor-induced hepatitis represents a rare but life-threatening complication for which therapeutic options are limited once corticosteroids and immunosuppressants fail. Our study provides the first multicenter evidence suggesting that therapeutic plasma exchange (TPE) is a feasible and safe approach that may improve hepatic outcomes in this setting. These findings are particularly relevant for oncologists, hepatologists, and intensivists facing refractory immune checkpoint inhibitor-induced liver injury, as TPE could offer a bridge to recovery when liver transplantation is not feasible. Early consideration of TPE, alongside careful patient selection, could optimize outcomes, although larger prospective studies are required to confirm efficacy and define the best timing and indications.
Authors
- Marwin A. Farrugia (ORCID: https://orcid.org/0000-0001-5264-5925)
- Fanny Lebossé (ORCID: https://orcid.org/0000-0002-3411-1580)
- Astrid Laurent-Bellue
- Christophe Chambon (ORCID: https://orcid.org/0000-0003-0357-9807)
- Lina Hountondji (ORCID: https://orcid.org/0000-0002-1039-7836)
- Clément Monet (ORCID: https://orcid.org/0000-0001-9884-6562)
- Ariane Laparra (ORCID: https://orcid.org/0000-0002-8275-7044)
- Philippe Ichaı̈ (ORCID: https://orcid.org/0000-0001-6182-4802)
- Lucy Meunier (ORCID: https://orcid.org/0000-0001-5697-286X)
- A. Maria (ORCID: https://orcid.org/0000-0002-0868-5804)
- Antonio Saviano (ORCID: https://orcid.org/0000-0001-7585-472X)
- Olivier Moranne (ORCID: https://orcid.org/0000-0002-3127-1415)
- François Villeret (ORCID: https://orcid.org/0000-0002-9327-4590)
- Mialy Randrianarisoa
- Marion Khaldi
- Simona Tripon
- Rodolphe Anty (ORCID: https://orcid.org/0000-0002-8053-1957)
- Eleonora De Martin
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Lyon College (US)
- Université Paris-Saclay (FR)
- Institut Gustave Roussy (FR)
- Centre Hospitalier Universitaire de Nantes (FR)
- Centre Hospitalier Universitaire de Montpellier (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hospices Civils de Lyon (FR)
- Centre Hospitalier Universitaire de Nîmes (FR)
- Hôpital l'Archet (FR)
- Hôpital Saint Eloi (FR)
- Bicêtre Hospital (FR)
- Hôpital Paul-Brousse (FR)
- Université de Strasbourg (FR)
- Nantes Université (FR)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101684
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00