PIEZO mechanosensitivity in chondrocytes is differentially modulated by L-type and T-type voltage-sensitive ion channels
In addition to contributing to the current understanding of the mechanisms through which VGCCs modify chondrocyte mechanobiology, our findings suggest the potential of L-type VGCC inhibitors as therapeutic targets for decreasing PIEZO1 signaling and reducing chondrocyte death in response to supraphysiologic mechanical loads.
Authors
- Robert J. Nims (ORCID: https://orcid.org/0000-0002-0856-3188)
- Alireza Savadipour (ORCID: https://orcid.org/0000-0002-6395-6558)
- Jaquelin M. Garcia‐Castorena (ORCID: https://orcid.org/0000-0002-1245-1891)
- Wolfgang Liedtke (ORCID: https://orcid.org/0000-0003-4166-5394)
- Farshid Guilak (ORCID: https://orcid.org/0000-0001-7380-0330)
- Gabrielle K. Marushack
Institutions
- Duke University (US)
- Washington University in St. Louis (US)
- Shriners Hospitals for Children - St. Louis (US)
- New York University (US)
Publication Details
- Journal
- Osteoarthritis and Cartilage Open
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1016/j.ocarto.2025.100710
- Citations
- 1
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 1.16