Disruption of Rab9-dependent mitophagy contributes to menopause-induced sarcopenia
This study demonstrates that estrogen deficiency impairs mitophagy originated from Rab9-dependent alternative autophagy, leading to mitochondrial dysfunction and sarcopenia, while enhancement of Rab9 restores mitochondrial quality control and muscle function. These results identify Rab9-dependent mitophagy as a potential therapeutic target for postmenopausal sarcopenia.
Authors
- Yoshiyuki Ikeda
- Yuichi Akasaki (ORCID: https://orcid.org/0000-0003-1488-310X)
- Shota Uebo
- Takuro Kubozono (ORCID: https://orcid.org/0000-0001-6055-1259)
- Yoshihiro Uchikado
- Yuichi Sasaki
- Mitsuru Ohishi
Institutions
- Kagoshima University (JP)
- Kagoshima Medical Center (JP)
Publication Details
- Journal
- Experimental Gerontology
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1016/j.exger.2025.112970
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00