Redox status regulates eggshell color by modulating protoporphyrin IX biosynthesis via the SIRT1/PGC-1α/ALAS1 axis in brown-shelled hens
Oxidative stress induces eggshell depigmentation by impairing mitochondrial function and downregulating the SIRT1/PGC-1α/ALAS1 pathway, leading to reduced PpIX biosynthesis. Specifically, vanadium-induced or endogenous oxidative stress disrupts mitochondrial energy metabolism and suppresses key components of this pathway, while resveratrol alleviates oxidative damage and restores mitochondrial function and ALAS1-driven PpIX synthesis through reactivation of the SIRT1/PGC-1α axis.
Authors
- Yu Fu (ORCID: https://orcid.org/0000-0001-6252-3075)
- Jing Wang (ORCID: https://orcid.org/0000-0003-3694-6001)
- Dongming Liu (ORCID: https://orcid.org/0000-0002-2623-8637)
- Mingyuan Lu
- Guanghai Qi (ORCID: https://orcid.org/0000-0002-1540-9525)
- Jianping Wang (ORCID: https://orcid.org/0000-0002-6596-8771)
- Haijun Zhang (ORCID: https://orcid.org/0000-0002-9149-600X)
Institutions
- Sichuan Agricultural University (CN)
- Chinese Academy of Agricultural Sciences (CN)
- Feed Research Institute (CN)
- Ministry of Agriculture and Rural Affairs (CN)
Publication Details
- Journal
- Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1186/s40104-025-01292-9
- Citations
- 1
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 1.22
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Chinese Academy of Agricultural Sciences
- Agricultural Science and Technology Innovation Program