<scp>11-</scp> Oxygenated Androgens Inhibit Brown Adipose Tissue Differentiation
11-Oxygenated androgens at high concentrations directly inhibit brown adipocyte differentiation in vitro and KT acutely downregulates BAT metabolic transcriptome in vivo, a result not observed with KDHT. These findings suggest that elevated 11-oxygenated androgens may impair BAT function, contributing to metabolic complications associated with hyperandrogenic conditions, including PCOS.
Authors
- Jacobie Steenbergen
- Yini Yuan
- Alba Sabaté-Pérez (ORCID: https://orcid.org/0000-0001-8257-6406)
- Alessandra C. Goulart (ORCID: https://orcid.org/0000-0003-1076-5210)
- Jenny A. Visser (ORCID: https://orcid.org/0000-0001-7182-3571)
Institutions
- Erasmus MC (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Endocrinology
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1210/endocr/bqaf172
- Citations
- 2
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.33