Rac1 inhibition promotes antitumor activity of statins in bone-seeking breast cancer cells
Genetic inhibition of Rac1 sensitizes osteotropic TNBC cell lines to statin treatment. Our results support a pro-tumorigenic function of Rac1 and indicate a potential benefit of combining Rac1 inhibition with statin treatment in osteotropic TNBC.
Authors
- Tilman D. Rachner (ORCID: https://orcid.org/0000-0002-1592-4666)
- Andy Göbel (ORCID: https://orcid.org/0000-0003-0918-4064)
- Lorenz Christian Hofbauer (ORCID: https://orcid.org/0000-0002-8691-8423)
- Romy M Anger
Institutions
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- Technische Universität Dresden (DE)
Publication Details
- Journal
- Biochemical and Biophysical Research Communications
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1016/j.bbrc.2025.152967
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00