Development and validation of a prognostic prediction model for gastric cancer based on lipophagy-related genes

In this study, a risk model was constructed based on five prognostic genes (AKAP12, BST1, DCBLD1, PDK4, and SPART). A nomogram was established by integrating each patient's risk score and clinical features (age, gender, and tumor stage). This model exhibits preliminary prognostic discrimination ability in both the training set and the validation set; however, its predictive accuracy is limited and requires further optimization.

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Publication Details

Journal
Translational Cancer Research
Published
2025-10-01
DOI
https://doi.org/10.21037/tcr-2025-725
Primary Topic
Ferroptosis and cancer prognosis
Type
article
Field-Weighted Citation Impact
0.00
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article

Development and validation of a prognostic prediction model for gastric cancer based on lipophagy-related genes

Dongfeng Song, Laibijiang Wusiman, Alimu Tulahong, X D Wei et al.
Translational Cancer Research
Ferroptosis and cancer prognosis
article

Development and validation of a prognostic prediction model for gastric cancer based on lipophagy-related genes

Dongfeng Song, Laibijiang Wusiman, Alimu Tulahong, X D Wei, Wenbin Zhang, Shu He, Juan Liu, Abulajiang Abudukelimu
article en

Abstract

In this study, a risk model was constructed based on five prognostic genes (AKAP12, BST1, DCBLD1, PDK4, and SPART). A nomogram was established by integrating each patient's risk score and clinical features (age, gender, and tumor stage). This model exhibits preliminary prognostic discrimination ability in both the training set and the validation set; however, its predictive accuracy is limited and requires further optimization.

Translational Cancer ResearchVol. 14(10)
Xinjiang Medical University (CN)
Openalex Percentile: Top 49%
Ferroptosis and cancer prognosis
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