New aminoglycoside from the aerial parts of <i>Ruehssia caatingae</i> (Apocynaceae)

A new aminoglycoside N-Galacted Amino Acid, (3-methylpentanoic acid-<i>β</i>-<i>D</i>-galactofuranoside) <b>(1)</b> and two previously identified metabolites, (-)-conduritol F <b>(2)</b> and thymidine <b>(3),</b> were isolated of dried aerial parts of <i>R. caatingae</i> (Apocynaceae). The structure elucidation of these compounds was based on analyses of spectroscopic data including 1D, 2D NMR, IR and HR-ESI-MS techniques and by comparing their NMR data with those reported in the literature. Furthermore, the cytotoxic potential of compounds <b>1</b>, <b>2</b> and <b>3</b> was evaluated by testing them against a panel of glioblastoma (U87-MG), neuroblastoma (SH-SY5Y) and breast adenocarcinoma (MDA-MB-231) cancer cell lines. All substances tested did not promote a minimum cytotoxicity of 50% in the tumour cell lines submitted to this assay.