Safety profile of enfortumab vedotin plus pembrolizumab in locally advanced or metastatic urothelial carcinoma: a multicenter Japanese cohort study
EVP demonstrated favorable early efficacy in Japanese patients but was associated with frequent early discontinuation due to AEs, particularly cutaneous toxicity. Early skin care and interdisciplinary management are essential. These findings support EVP use while emphasizing AE management and patient-centered care.
Authors
- Mimu Ishikawa
- Yuma Waki (ORCID: https://orcid.org/0000-0003-4532-3316)
- Fumihiko Urabe (ORCID: https://orcid.org/0000-0002-2599-8183)
- Kensuke Fujiwara (ORCID: https://orcid.org/0000-0001-8284-7982)
- Kosuke Iwatani (ORCID: https://orcid.org/0000-0001-5428-852X)
- Wataru Fukuokaya (ORCID: https://orcid.org/0000-0003-1044-912X)
- Jun Miki (ORCID: https://orcid.org/0000-0002-4638-8640)
- Shunsuke Tsuzuki
- Shun Saito (ORCID: https://orcid.org/0000-0001-9270-4272)
- Keiichiro Mori (ORCID: https://orcid.org/0000-0002-6147-6569)
- Masaya Murakami (ORCID: https://orcid.org/0000-0002-1268-6615)
- Takafumi Yanagisawa (ORCID: https://orcid.org/0000-0002-7410-0712)
- Kojiro Tashiro
- Kanako Kasai
- Sotaro Kayano (ORCID: https://orcid.org/0009-0001-0895-1551)
- Shuhei Hara (ORCID: https://orcid.org/0009-0001-9842-3612)
- Shota Kawano
- Yu Imai (ORCID: https://orcid.org/0000-0003-0971-4205)
- Takahiro Kimura (ORCID: https://orcid.org/0000-0002-5673-1553)
- Juria Nakano
Institutions
- Jikei University School of Medicine (JP)
- Tsukuba Memorial Hospital (JP)
- Katsushika Medical Center (JP)
- Tokyo-Kita Medical Center (JP)
- The Jikei University Hospital (JP)
- Tokyo Metropolitan Hiroo Hospital (JP)
- Fujieda Municipal General Hospital (JP)
- Jikei University Kashiwa hospital (JP)
- Fuji Heavy Industries Health Insurance Society Ota Memorial Hospital (JP)
- Oida Hospital (JP)
- JR Tokyo General Hospital (JP)
- Tsurugi Hospital (JP)
Publication Details
- Journal
- Japanese Journal of Clinical Oncology
- Published
- 2025-11-19
- DOI
- https://doi.org/10.1093/jjco/hyaf182
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00