Motor stereotypies, <i>Dhat</i> syndrome, and gaming disorder: A masquerading presentation of Wilson's disease

Wilson's disease, a rare genetic disorder caused by ATP7B gene mutations, disrupts copper metabolism, often presenting with psychiatric symptoms in 20-30% of cases before diagnosis. Diagnostic challenges arise owing to non-specific symptoms, leading to potential misdiagnosis. <i>Dhat</i> syndrome, a culture-bound syndrome prevalent in the Indian subcontinent, involves distress over perceived semen loss and, thus, the loss of vitality. We report a case of a young male with <i>dhat</i> syndrome, asymmetrical hand movements, behavioural changes, and gaming disorder who, after long being treated for functional neurological disorder, was later diagnosed with Wilson's disease after a comprehensive evaluation.

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Publication Details

Journal
Tropical Doctor
Published
2025-11-19
DOI
https://doi.org/10.1177/00494755251396674
Primary Topic
Trace Elements in Health
Type
article
Field-Weighted Citation Impact
0.00
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article

Motor stereotypies, Dhat syndrome, and gaming disorder: A masquerading presentation of Wilson's disease

Rakesh Kumar Chadda, Divya Madathiparambil Radhakrishnan, Omar Afroz, Romil Saini et al.
Tropical Doctor
Trace Elements in Health
article

Motor stereotypies, Dhat syndrome, and gaming disorder: A masquerading presentation of Wilson's disease

Rakesh Kumar Chadda, Divya Madathiparambil Radhakrishnan, Omar Afroz, Romil Saini, Koushik Sinha Deb, Raja Babu Ramawat
article en

Abstract

Wilson's disease, a rare genetic disorder caused by ATP7B gene mutations, disrupts copper metabolism, often presenting with psychiatric symptoms in 20-30% of cases before diagnosis. Diagnostic challenges arise owing to non-specific symptoms, leading to potential misdiagnosis. <i>Dhat</i> syndrome, a culture-bound syndrome prevalent in the Indian subcontinent, involves distress over perceived semen loss and, thus, the loss of vitality. We report a case of a young male with <i>dhat</i> syndrome, asymmetrical hand movements, behavioural changes, and gaming disorder who, after long being treated for functional neurological disorder, was later diagnosed with Wilson's disease after a comprehensive evaluation.

Tropical DoctorVol. 56(2)
Amrita Institute of Medical Sciences and Research Centre (IN), Sanjay Gandhi Post Graduate Institute of Medical Sciences (IN), Asian Institute of Medical Sciences (IN), All India Institute of Medical Sciences (IN)
Openalex Percentile: Top 58%
Trace Elements in Health
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