NUAK1 Promotes Diabetic Kidney Disease by Accelerating Renal Tubular Senescence via the ROS/P53 Axis
Mechanisms linking renal tubular senescence to diabetic kidney disease (DKD) progression remain poorly understood. Systematic elucidation of the regulatory role of NUAK1 in the pathogenesis of DKD and its regulatory mechanisms is provided. NUAK1 is upregulated in DKD, promoting senescence via reactive oxygen species-tumor protein 53 under transcriptional activation by E26 transformation-specific 1, while Asiatic acid (AA) directly binds NUAK1 to suppress these pathological processes. NUAK1 emerges as a therapeutic target for DKD, and AA provides a natural scaffold for NUAK1 inhibitor development, offering a strategy to combat diabetes-related renal decline.
Authors
- Yaoming Xue (ORCID: https://orcid.org/0000-0003-1356-4780)
- Meiping Guan (ORCID: https://orcid.org/0000-0002-9709-9320)
- Feifei Cai
- Xinzhao Fan
- Qijian Feng
- Shun Luo
- Lei Guo (ORCID: https://orcid.org/0009-0009-2638-8027)
- Ling Wang (ORCID: https://orcid.org/0000-0001-6043-5661)
- Qing Li (ORCID: https://orcid.org/0000-0003-4807-030X)
- Jin Zhang (ORCID: https://orcid.org/0000-0001-7145-7823)
- Yuan Wang (ORCID: https://orcid.org/0000-0001-9350-4061)
- Yibin Wang (ORCID: https://orcid.org/0000-0003-0852-0767)
- Yuling Luo
- Huiyun Wang
- Peili Wu
- Xiaochun Lin
- Linlin Tian
- Yuxuan Hu (ORCID: https://orcid.org/0009-0004-3558-4584)
- Minghai Wu
Institutions
- Zhujiang Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Diabetes
- Published
- 2025-11-20
- DOI
- https://doi.org/10.2337/db25-0417
- Citations
- 1
- Primary Topic
- NF-κB Signaling Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.94