Spermidine Secreted by Apoptotic Cells Enhances Chemotherapy Resistance by Modulating β-Catenin Activity in Osteosarcoma
These findings illuminate the critical role of apoptotic cell metabolites in mediating treatment resistance and suggest that targeting SPD may offer a promising therapeutic strategy to augment the effectiveness of chemotherapy in osteosarcoma.
Authors
- Xiaojian Ye (ORCID: https://orcid.org/0009-0001-2872-9253)
- Shichao Tong (ORCID: https://orcid.org/0009-0008-5751-1000)
- Qifeng Yu (ORCID: https://orcid.org/0009-0003-2541-3207)
- Yanghu Lu (ORCID: https://orcid.org/0009-0007-6127-9163)
- Xiangyang Zhang (ORCID: https://orcid.org/0009-0009-5015-9478)
- Zhikun Li (ORCID: https://orcid.org/0000-0002-0850-1323)
- Yi Wang (ORCID: https://orcid.org/0009-0007-2998-0865)
- Wei Xu (ORCID: https://orcid.org/0000-0002-0720-1652)
- Mei Geng (ORCID: https://orcid.org/0009-0005-9032-3579)
Institutions
- Shanghai Jiao Tong University (CN)
- Ruijin Hospital (CN)
- Tongren Hospital (CN)
- Shanghai Institute of Hematology (CN)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-4275
- Primary Topic
- Polyamine Metabolism and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00