Emergence of a ceftriaxone-resistant <i>Neisseria gonorrhoeae</i> strain harbouring <i>penA</i> -60.001 in a novel genetic background (MLST 9903) in Japan, 2018–2024
An <i>N. gonorrhoeae</i> strain carrying the <i>penA</i>-60.001 allele was identified in Japan again, after not being reported since 2017. Based on a phylogenetic analysis, the strain originated from a different lineage than that of the previously dominant MLST 1903 strain in Japan. Transformation studies showed that new CRO-resistant <i>N. gonorrhoeae</i> strains could emerge from the gDNA of the MLST 9903 strain that was isolated.
Authors
- Takuya Kawahata (ORCID: https://orcid.org/0000-0003-3336-4188)
- Yukihiro Akeda (ORCID: https://orcid.org/0000-0002-5325-4173)
- Akio Yoshida
- Shu‐ichi Nakayama (ORCID: https://orcid.org/0000-0002-1495-0926)
- Yuki Ohama (ORCID: https://orcid.org/0000-0002-1818-5029)
- Ken Shimuta (ORCID: https://orcid.org/0000-0002-1416-4116)
- Hideyuki Takahashi (ORCID: https://orcid.org/0000-0001-8934-8043)
- Makoto Ohnishi
Institutions
- National Institute of Infectious Diseases (JP)
- Osaka Prefectural Institute of Public Health (JP)
- Okinawa Prefectural Institute of Health and Environment (JP)
Publication Details
- Journal
- Sexually Transmitted Infections
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1136/sextrans-2025-056694
- Primary Topic
- Reproductive tract infections research
- Type
- article
- Field-Weighted Citation Impact
- 0.00