FOXM1 inhibition reduces IL-13-induced epithelial remodelling and inflammation in eosinophilic oesophagitis
FOXM1 plays a pivotal role in epithelial disruption in EoE by driving proliferation and impairing differentiation. Targeting FOXM1 restores epithelial homeostasis, mitigates inflammation and offers a novel therapeutic approach for EoE.
Authors
- Emily A. McMillan
- Satoshi Ishikawa (ORCID: https://orcid.org/0000-0002-6015-8921)
- Mark Mahon (ORCID: https://orcid.org/0000-0002-7548-7939)
- Melanie A. Ruffner (ORCID: https://orcid.org/0000-0002-2943-9944)
- Sydney M. Shaffer (ORCID: https://orcid.org/0000-0003-3539-9886)
- Joshua X. Wang (ORCID: https://orcid.org/0000-0002-9949-798X)
- Ryugo Teranishi (ORCID: https://orcid.org/0000-0001-9337-0526)
- Holli Winters
- Kelly A. Whelan (ORCID: https://orcid.org/0000-0001-7402-4935)
- Kanak V. Kennedy
- Heather Golden
- Yusen Zhou (ORCID: https://orcid.org/0000-0002-9830-682X)
- Toshiaki Itami
- Benjamin J. Wilkins (ORCID: https://orcid.org/0000-0002-1797-7323)
- Alyssa Baccarella (ORCID: https://orcid.org/0000-0001-8200-9751)
- Tatiana A. Karakasheva (ORCID: https://orcid.org/0000-0001-9070-2804)
- Amanda B. Muir (ORCID: https://orcid.org/0000-0003-2616-7063)
- Chizoba N. Umeweni
- Masaru Sasaki (ORCID: https://orcid.org/0000-0002-6618-2586)
- Ann Semeao
- Diya Dhakal
Institutions
- Children's Hospital of Philadelphia (US)
- University of Pennsylvania (US)
- Temple University (US)
- Stanford University (US)
Publication Details
- Journal
- Gut
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1136/gutjnl-2025-335163
- Citations
- 1
- Primary Topic
- Eosinophilic Esophagitis
- Type
- article
- Field-Weighted Citation Impact
- 2.01