Psychotropic drugs in pregnancy and lactation
Whenever possible, medications should be avoided in the first trimester, with the lowest effective dose used throughout pregnancy. In severe cases, drugs cannot be stopped as discontinuation can lead to relapse, but they require individualized risk-benefit assessments. For lactating mothers, drugs with established safety profiles should be prioritized. Further research is needed to clarify long-term effects and support evidence-based decisions in maternal mental health care.
Authors
- Francesco Weiss (ORCID: https://orcid.org/0000-0003-1935-5162)
- Alessandro Arone (ORCID: https://orcid.org/0000-0003-4398-6837)
- Donatella Marazziti (ORCID: https://orcid.org/0000-0002-4021-5829)
- Giulio Perugi (ORCID: https://orcid.org/0000-0001-5556-1858)
- Riccardo Gurrieri (ORCID: https://orcid.org/0009-0009-0743-178X)
- Gerardo Russomanno
- Lara Foresi Crawther
Institutions
- University of Pisa (IT)
Publication Details
- Journal
- Expert Opinion on Drug Metabolism & Toxicology
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1080/17425255.2025.2593995
- Primary Topic
- Maternal Mental Health During Pregnancy and Postpartum
- Type
- article
- Field-Weighted Citation Impact
- 0.00