Neurometabolic signatures of gastrointestinal symptoms in the insula of Crohn’s disease patients: explorative findings from a 7T MRS study
The neurometabolic alterations observed in the insular cortex of Crohn's disease patients suggest increased insular activity, which may enhance interoceptive awareness and pain sensitivity, potentially contributing to heightened pain catastrophizing.
Authors
- Ezequiel Farrher (ORCID: https://orcid.org/0000-0003-2902-8667)
- Ravichandran Rajkumar (ORCID: https://orcid.org/0000-0001-5875-5316)
- Kai Markus Schneider (ORCID: https://orcid.org/0000-0002-0047-3794)
- Hanna Hartmann (ORCID: https://orcid.org/0000-0001-9643-998X)
- Irene Neuner (ORCID: https://orcid.org/0000-0002-5164-8873)
- Julius Jaeger (ORCID: https://orcid.org/0000-0002-1122-5331)
- N. Jon Shah (ORCID: https://orcid.org/0000-0002-8151-6169)
- Markus Zimmermann (ORCID: https://orcid.org/0000-0003-1273-5218)
- Malin Berthold
Institutions
- Forschungszentrum Jülich (DE)
- Düsseldorf University Hospital (DE)
- Fresenius (Germany) (DE)
- Universitätsklinikum Aachen (DE)
- Jülich Aachen Research Alliance (DE)
- University Hospital Carl Gustav Carus (DE)
- Heinrich Heine University Düsseldorf (DE)
- Technische Universität Dresden (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- Frontiers in Human Neuroscience
- Published
- 2025-11-20
- DOI
- https://doi.org/10.3389/fnhum.2025.1620488
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00