Isoquinoline Alkaloids From <i>Fibraurea recisa</i> With Anti‐acetylcholinesterase Activity
Two new 8-oxoprotoberberine alkaloids (1 and 2), one new isoquinoline alkaloid (8), and a pair of enantiomeric isoindolebenzazepine alkaloids (10a and 10b) were isolated from the vine stems of Fibraurea recisa Pierre. Their structures and absolute configurations were elucidated by spectroscopic methods (mass spectrometry, ultraviolet, infrared, one- and two-dimensional nuclear magnetic resonance), quantum chemical electronic circular dichroism calculations, and single-crystal X-ray crystallography. All isolated compounds were evaluated for acetylcholinesterase inhibitory activity, with compound 4 exhibiting significant inhibition.
Authors
- Hui Sun (ORCID: https://orcid.org/0009-0005-5127-3273)
- Qianyi Situ
- Yu Zhang (ORCID: https://orcid.org/0000-0003-3474-422X)
- Jianhui He
- Guo‐Cai Wang (ORCID: https://orcid.org/0000-0003-1196-7850)
- Kai Zhao (ORCID: https://orcid.org/0000-0001-5638-5219)
- Qing Tang (ORCID: https://orcid.org/0000-0001-7419-1960)
- Hai‐Yue Zhao
- Huihui Zhu (ORCID: https://orcid.org/0000-0002-4541-9695)
- Miao Wang (ORCID: https://orcid.org/0000-0003-0802-996X)
- Ke‐Han Pei
Institutions
- Jinan University (CN)
- Hunan Provincial Center for Disease Control and Prevention (CN)
- Zhuzhou Central Hospital (CN)
Publication Details
- Journal
- Chemistry & Biodiversity
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1002/cbdv.202503015
- Primary Topic
- Berberine and alkaloids research
- Type
- article
- Field-Weighted Citation Impact
- 0.00