ChemR23 prevents phenotypic switching of vascular smooth muscle cells into macrophage-like foam cells in atherosclerosis
These findings suggest a critical role of ChemR23 in regulating VSMC phenotype switching thereby affecting atherosclerosis and suggest ChemR23 as a therapeutic target to either modulate inflammation (C9) or macrophage polarization (α-N-ethyl-3-(4-(trifluoromethyl)phenyl)acetamide; α-NETA) in atherosclerotic disease.
Authors
- Nico Angliker
- Alexander Bartelt (ORCID: https://orcid.org/0000-0001-7840-3991)
- Nadja Sachs (ORCID: https://orcid.org/0000-0001-8031-017X)
- Bryce Evans (ORCID: https://orcid.org/0000-0002-6221-4325)
- Floriana Maria Farina (ORCID: https://orcid.org/0000-0002-5105-5672)
- Marc Schindewolf (ORCID: https://orcid.org/0000-0003-4597-0759)
- Emiel P. C. van der Vorst (ORCID: https://orcid.org/0000-0001-5771-6278)
- Lars Mäegdefessel (ORCID: https://orcid.org/0000-0001-5228-2634)
- Mark Siegrist
- Yvonne Jansen (ORCID: https://orcid.org/0000-0002-1283-8260)
- Yvonne Döring (ORCID: https://orcid.org/0000-0001-9307-3396)
- Christoph Gold (ORCID: https://orcid.org/0009-0008-8994-1021)
- Sanne L. Maas (ORCID: https://orcid.org/0000-0003-1423-8901)
- Yi Yan (ORCID: https://orcid.org/0000-0003-2860-3252)
- Donato Santovito (ORCID: https://orcid.org/0000-0003-1811-4746)
- Manovriti Thakur (ORCID: https://orcid.org/0000-0003-3825-4121)
- Anaïs Yerly (ORCID: https://orcid.org/0009-0009-4058-2010)
- Heidi Noels (ORCID: https://orcid.org/0000-0003-3053-6984)
- Justus Wettich
- Christian Weber (ORCID: https://orcid.org/0000-0003-4610-8714)
- Julia Schulz (ORCID: https://orcid.org/0000-0001-5285-0099)
- Drosos Kotelis
- Vasiliki Triantafyllidou
- B. Bayer
Institutions
- University of Bern (CH)
- Translational Research Institute (AU)
- Maastricht University Medical Centre (NL)
- University Hospital of Bern (CH)
- TUM Klinikum (DE)
- Karolinska Institutet (SE)
- LMU Klinikum (DE)
- Maastricht University (NL)
- Shanghai Children's Medical Center (CN)
- Southern California Clinical and Translational Science Institute (US)
- Munich Cluster for Systems Neurology (DE)
- Adult Congenital Heart Association (US)
- Universitätsklinikum Aachen (DE)
- German Centre for Cardiovascular Research (DE)
- Shanghai Clinical Research Center (CN)
- Ludwig-Maximilians-Universität München (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-11-19
- DOI
- https://doi.org/10.1093/cvr/cvaf258
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Novartis Foundation
- University of Bern
- Deutsches Zentrum für Herz-Kreislaufforschung
- Corona-Stiftung
- Deutsche Forschungsgemeinschaft
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- National Natural Science Foundation of China
- Schweizerische Herzstiftung
- RWTH Aachen University