A 20-year FAERS analysis of hypersensitivity reports to chlorhexidine and povidone-iodine (2004-2024)

Hypersensitivity reports to CHX, particularly dermatitis and urticaria, are rising rapidly. Although povidone-iodine hypersensitivity reports remain lower, their steady rise warrants continued surveillance and clinical awareness. Improving patient safety surrounding these events requires greater clinical awareness, routine assessment for previous sensitivities, thorough evaluation following suspected reactions, and development of accurate diagnostic tools.