GDF15 is a putative biomarker for distinguishing pulmonary veno-occlusive disease and pulmonary arterial hypertension
Study identifies GDF15 as a biomarker-accurately distinguishing PVOD from other PAH forms and predicting outcomes across PVOD, IPAH, and HPAH-advancing earlier diagnosis and personalized treatment.
Authors
- Luke Howard (ORCID: https://orcid.org/0000-0003-2822-210X)
- Amit Prabhakar (ORCID: https://orcid.org/0000-0002-9263-7038)
- Tin Aung
- Steven R. Hays (ORCID: https://orcid.org/0000-0002-2887-8451)
- Colin Church (ORCID: https://orcid.org/0000-0002-4446-0100)
- Paul J. Wolters (ORCID: https://orcid.org/0000-0002-3108-6164)
- John R. Greenland (ORCID: https://orcid.org/0000-0003-1422-8367)
- Mark R. Toshner (ORCID: https://orcid.org/0000-0002-3969-6143)
- Jonathan Paul Singer (ORCID: https://orcid.org/0000-0003-0224-7472)
- S. Carter
- Stefan Ting Graf (ORCID: https://orcid.org/0000-0002-0181-8846)
- SJ Wort
- Prajakta Ghatpande
- Jacqueline T. DesJardin (ORCID: https://orcid.org/0000-0002-6632-8995)
- Marc A. Simon
- Eckart M. D. D. De Bie (ORCID: https://orcid.org/0000-0002-1595-1226)
- Michael Wax
- Akiko Hata (ORCID: https://orcid.org/0000-0003-3784-1738)
- Jasleen Kukreja (ORCID: https://orcid.org/0000-0003-2991-6680)
- Giorgio Lagna (ORCID: https://orcid.org/0000-0001-9228-4554)
- David G. Kiely
- Emily Sumpena (ORCID: https://orcid.org/0009-0003-7701-0821)
Institutions
- Imperial College Healthcare NHS Trust (GB)
- University of California, San Francisco (US)
- University of Cambridge (GB)
- Hammersmith Hospital (GB)
- Golden Jubilee National Hospital (GB)
- Royal Brompton Hospital (GB)
- Lung Institute (US)
- Sheffield Teaching Hospitals NHS Foundation Trust (GB)
- Papworth Hospital NHS Foundation Trust (GB)
- Pulmonary and Allergy Associates (US)
- Comprehensive Cardiovascular (US)
- San Francisco VA Health Care System (US)
- Imperial College London (GB)
Publication Details
- Journal
- Journal of Clinical Investigation
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1172/jci199159
- Primary Topic
- GDF15 and Related Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute for Health and Care Research
- British Heart Foundation
- Cambridge Trust
- Gates Cambridge Trust
- National Institutes of Health