Integration of blaOXA-48 into a Col156 plasmid drove a carbapenem-resistant Escherichia coli ST131 outbreak in New Zealand: Global genomic evidence for the gene’s multilayered dissemination
This is the first high-resolution genomic reconstruction of a community-associated bla<sub>OXA-48</sub> outbreak, identifying a compact Col156 plasmid as a key vector driving carbapenem resistance. Our findings demonstrate the value of complete genome assemblies and pangenome graph analyses in resolving the structural and evolutionary dynamics of antimicrobial resistance.
Authors
- Kristin Dyet (ORCID: https://orcid.org/0000-0003-2508-6843)
- Michael Harrington (ORCID: https://orcid.org/0000-0001-5342-8834)
- Rhys T. White (ORCID: https://orcid.org/0000-0001-6620-758X)
- Max Bloomfield (ORCID: https://orcid.org/0000-0002-3920-7151)
- Hermes Perez
- Jenny Szeto
- Allan J. Hardaker
- Craig Thornley (ORCID: https://orcid.org/0000-0001-9280-6260)
- David J. Winter (ORCID: https://orcid.org/0000-0002-6165-0029)
- Rosemary Woodhouse (ORCID: https://orcid.org/0000-0002-5670-4969)
- Simon A. Jackson (ORCID: https://orcid.org/0000-0002-4512-3093)
- Zuyu Yang
- Xiaoyun Ren (ORCID: https://orcid.org/0000-0002-5163-9715)
- Annette Nesdale
- Matthew James Kelly (ORCID: https://orcid.org/0000-0001-7963-2139)
- Claire Underwood
- Loushy Mangalasseril
- Juliet Elvy (ORCID: https://orcid.org/0009-0001-4482-6758)
Institutions
- Ministry of Health (NZ)
- Dunedin Public Hospital (NZ)
- Hutt Hospital (NZ)
- Capital and Coast District Health Board (NZ)
- Building Research Association of New Zealand (NZ)
- University of Waikato (NZ)
Publication Details
- Journal
- Drug Resistance Updates
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.drup.2025.101327
- Citations
- 1
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.59