Sensitive periods for the link between childhood maltreatment and brain aging during adulthood
These findings suggest a link between CM and accelerated brain aging, with certain developmental periods appearing more sensitive to these effects. To the best of our knowledge, this study is the first to identify sensitive periods for the link between CM and brain aging in adults, and the first to examine the link between CM and brain aging in postnatal women. Together, these results suggest that CM's association with brain development is complex and warrants nuanced approaches to investigating the possible mechanisms underlying its effects.
Authors
- Michelle Bosquet Enlow (ORCID: https://orcid.org/0000-0003-2598-3894)
- Kyoko Ohashi (ORCID: https://orcid.org/0000-0002-9482-606X)
- Martin H. Teicher (ORCID: https://orcid.org/0000-0002-6036-0177)
- Jennifer E. Khoury (ORCID: https://orcid.org/0000-0002-6703-4198)
- Torsten Klengel (ORCID: https://orcid.org/0000-0001-7045-9229)
- Karlen Lyons‐Ruth (ORCID: https://orcid.org/0000-0001-9799-976X)
- Leland L. Fleming (ORCID: https://orcid.org/0000-0002-4047-9031)
- Kerry James Ressler (ORCID: https://orcid.org/0000-0002-5158-1103)
Institutions
- Boston Children's Hospital (US)
- Harvard University (US)
- Mount Saint Vincent University (CA)
- McLean Hospital (US)
- Cambridge Hospital (US)
Publication Details
- Journal
- Neurobiology of Stress
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1016/j.ynstr.2025.100771
- Citations
- 2
- Primary Topic
- Child Abuse and Trauma
- Type
- article
- Field-Weighted Citation Impact
- 4.61