Genome-wide identification and characterization of methyltransferase involved in benzylisoquinoline alkaloids biosynthesis from Menispermum dauricum
This research elucidates the functional landscape of OMTs/NMTs in <i>M. dauricum</i>, revealing their crucial roles in BIA structural diversification. The newly identified enzymes provide valuable biocatalytic tools for synthetic biology approaches aimed at the sustainable and optimized production of high-value BIAs.
Authors
- Ya Tian (ORCID: https://orcid.org/0000-0001-9482-4307)
- Ge Bai (ORCID: https://orcid.org/0000-0002-6550-1557)
- Shancen Zhao
- Ziyuan Zhao (ORCID: https://orcid.org/0000-0002-4403-825X)
- Ranran Gao (ORCID: https://orcid.org/0000-0002-7164-0289)
- Yan Wang (ORCID: https://orcid.org/0000-0003-2057-0097)
- Zhoujie An (ORCID: https://orcid.org/0000-0002-1638-3179)
- Yaning Fu
- Yong Chen (ORCID: https://orcid.org/0000-0001-5857-6086)
- Yuwei Ma (ORCID: https://orcid.org/0009-0002-6692-1921)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Yunnan Academy of Agricultural Sciences (CN)
- State Forestry and Grassland Administration (CN)
- Shimadzu (China) (CN)
- Beijing Academy of Science and Technology (CN)
- Northeast Forestry University (CN)
Publication Details
- Journal
- Chinese Herbal Medicines
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.chmed.2025.11.007
- Primary Topic
- Berberine and alkaloids research
- Type
- article
- Field-Weighted Citation Impact
- 0.00