Bevacizumab plus chemotherapy versus chemotherapy in untreated advanced non-squamous non-small-cell lung cancer patients with brain metastases (BAP BRAIN): an open-label, randomized, multicenter, phase III study
This study demonstrated encouraging intracranial efficacy and acceptable safety of bevacizumab plus chemotherapy in patients with non-squamous NSCLC and brain metastases in the first-line setting.
Authors
- Miao Yu (ORCID: https://orcid.org/0000-0002-5945-7430)
- Qianqian Bu
- Caicun Zhou (ORCID: https://orcid.org/0000-0002-6958-0766)
- Shulan Ma (ORCID: https://orcid.org/0000-0002-8326-3134)
- Qin‐Tao Wang
- Xiaohua Hou (ORCID: https://orcid.org/0000-0002-3694-2126)
- Yunfeng Pan (ORCID: https://orcid.org/0000-0001-7459-4970)
- Qinqin Liu (ORCID: https://orcid.org/0000-0001-9299-453X)
- Huichuan Yu (ORCID: https://orcid.org/0000-0001-8357-1615)
- Ming Li (ORCID: https://orcid.org/0000-0001-6291-9328)
- Lin Chen (ORCID: https://orcid.org/0000-0002-1108-4735)
- Guoqing Wu
- Jiarong Chen (ORCID: https://orcid.org/0000-0001-7920-4249)
- Hongli Jiang (ORCID: https://orcid.org/0000-0003-4448-5508)
- Guoliang Jiang (ORCID: https://orcid.org/0009-0008-0844-1421)
- Weineng Feng
Institutions
- Sun Yat-sen University (CN)
- Guangxi Medical University (CN)
- Meizhou City People's Hospital (CN)
- People 's Liberation Army 451 Hospital (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- First People's Hospital of Foshan (CN)
- Dongguan People’s Hospital (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- Henan Cancer Hospital (CN)
- Sun Yat-sen University Cancer Center (CN)
- State Key Laboratory of Respiratory Disease (CN)
- State Key Laboratory of Oncology in South China
- Guangzhou Medical University (CN)
Publication Details
- Journal
- ESMO Open
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.esmoop.2025.105908
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00