Whole-exome ctDNA sequencing reveals intratumoral heterogeneity and drivers of relapse in locally advanced head and neck cancer
WES of ctDNA uncovers extensive ITH and identifies molecular drivers of resistance not captured by tissue biopsies. These findings support the use of plasma ctDNA analysis to monitor tumor evolution and personalize follow-up in LA-HNSCC, especially given the anatomical complexity that often limits repeated tissue sampling.
Authors
- Clara Alfaro‐Cervelló (ORCID: https://orcid.org/0000-0002-3737-4028)
- Blanca García-Micó (ORCID: https://orcid.org/0000-0002-9370-7966)
- María Maroñas
- Juan Antonio Carbonell‐Asins (ORCID: https://orcid.org/0000-0002-8449-5674)
- D. Dualde
- J. Martín-Arana
- G. Bruixola (ORCID: https://orcid.org/0000-0003-3229-0770)
- A. Cervantes
- Francisco Gimeno-Valiente (ORCID: https://orcid.org/0000-0003-0544-9459)
- N. Grimalt
- Vicente Escorihuela
- B. Martínez-Castedo (ORCID: https://orcid.org/0009-0002-3629-8526)
- M. García-Bartolomé
- N. Tarazona
- M E Iglesias
- D. González-Camblor
Institutions
- Universitat de València (ES)
- London Cancer (GB)
- Hospital Clínico Universitario de Valencia (ES)
- INCLIVA Health Research Institute (ES)
- University College London (GB)
Publication Details
- Journal
- ESMO Open
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.esmoop.2025.105904
- Citations
- 2
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Generalitat Valenciana
- INCLIVA Instituto de Investigación Sanitaria
- Fundación Fero
- Instituto de Salud Carlos III