Isolation, preliminary In Vitro screening, and In Vivo biosafety evaluation of a Siphoviridae bacteriophage against drug-resistant Salmonella Typhimurium

In conclusion, while the isolated Siphoviridae phage demonstrated potent In vitro activity against drug-resistant Salmonella Typhimurium strain, its administration to healthy rats induced measurable changes in both their blood profiles and tissue structures. These findings highlight the critical need for further safety and immunological studies before considering this phage for therapeutic use.