Dysregulated ITGA3/FAK/YAP axis mediates impaired alveolar type II epithelial cells function in COPD
Our study elucidates core regulatory role of ROS/ITGA3/FAK/YAP axis in AT2 cells renewal dysfunction in COPD by integrating single-cell genomics, preclinical models, and functional organoid studies, demonstrating ROS/ITGA3 as a new promising avenue for therapeutic intervention of COPD regeneration therapy.
Authors
- Kai-Jia Wang
- Jing Zhang (ORCID: https://orcid.org/0000-0002-1759-1041)
- Weiping Hu (ORCID: https://orcid.org/0000-0002-2432-5876)
- Suye Zhong
- Tengfei Zhou (ORCID: https://orcid.org/0000-0001-9370-2527)
- Li Liu (ORCID: https://orcid.org/0000-0001-6128-3284)
- Xiao Wang (ORCID: https://orcid.org/0000-0002-4967-3690)
- Xinhua Lin (ORCID: https://orcid.org/0000-0002-1063-749X)
- Yixing Wu (ORCID: https://orcid.org/0009-0008-3904-8710)
- Yue Ren (ORCID: https://orcid.org/0000-0003-1856-8633)
Institutions
- Fudan University (CN)
- Zhongshan Hospital (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1016/j.jare.2025.11.033
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 0.00