Evaluation of loco-regional recurrences using deformable image registration after isotoxic high dose stereotactic body radiotherapy in localised pancreatic cancer
Image based evaluation of loco-regional recurrence is an important part of the assessment of patients treated with iHD-SBRT for localised pancreatic cancer. DIR-based analysis emphasized the importance of expanding the tumor-vessel interface (TVI) structure in radiotherapy planning to include the full circumference of adjacent vessels with a 5 mm margin. DIR-based analysis highlighted that several marginal recurrences occurred in proximity to perivascular regions, suggesting a potential benefit of expanding perivascular target coverage in future treatment planning.
Authors
- Christelle Bouchart (ORCID: https://orcid.org/0000-0003-1714-234X)
- Jean-Luc Engelholm (ORCID: https://orcid.org/0000-0003-2149-0988)
- Sara Poeta
- Jean‐Luc Van Laethem (ORCID: https://orcid.org/0000-0002-0785-0580)
- Ákos Gulybán (ORCID: https://orcid.org/0000-0002-6805-8802)
- Martin Manderlier
Institutions
- Université Libre de Bruxelles (BE)
- Institut Jules Bordet (BE)
- Hôpitaux Iris Sud (BE)
- Grand Charleroi Hospital (BE)
Publication Details
- Journal
- Clinical and Translational Radiation Oncology
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.ctro.2025.101081
- Primary Topic
- Advanced Radiotherapy Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fonds De La Recherche Scientifique - FNRS
- Amis de l'Institut Bordet